Excessive alcohol use can cause a brain condition called “Wernicke's encephalopathy”. This is believed to occur as a direct result of vitamin B deficiency and can progress to a more permanent damage in the form of Korsakoff Syndrome/psychosis. The inability to learn new information is a core feature of Korsakoff Syndrome and a dementia associated with alcohol use. Correct establishment of the diagnosis can help with organisation of appropriate care for patients with this type of dementia.
Alcohol-related brain damage (ARBD) is a brain disorder caused by regularly drinking too much alcohol over several years. The term ARBD covers several different conditions including Wernicke-Korsakoff syndrome and alcoholic dementia. None of these is actually a dementia, but they may share similar symptoms. However, in contrast to common causes of dementia such as Alzheimer's disease, most people with ARBD who receive good support and remain alcohol-free make a full or partial recovery. In addition, there is a good possibility that their condition will not worsen.
Patterns of drinking in Great Britain have changed over the past 10 years. Middle-aged people are now the age group which consumes the most alcohol and they are drinking more than in the past, especially middle-aged women. In contrast, younger people (aged 16-24) are now drinking less, particularly when it comes to binge drinking. Against this background, ARBD is an under-recognised and growing problem.
Drinking more than the recommended limit for alcohol increases a person's risk of developing common types of dementia such asAlzheimer's disease and vascular dementia. The NHS recommended limits are now a maximum of 14 units each week for men and women, spread over 3 or more days - although lower limits have been suggested for older people because their bodies handle alcohol differently. A small 125ml glass of wine is typically about 1.5 units and a pint of beer, lager or cider is usually 2-2.5 units.
It seems that repeated binge drinking - heavy drinking in one session, often leading to drunkenness - is particularly harmful. Binge drinking is dangerous because it raises the amount of alcohol in the blood to a high level very quickly.
This increased risk of dementia is greatest at higher levels of alcohol consumption - the more you drink, the higher your risk. But you do not need to be an alcoholic or get drunk often to be at increased risk of developing dementia. Regularly drinking even a little above recommended levels probably increases your risk. It also increases your risk of other conditions such as stroke, heart and liver disease, and cancer.
Regularly drinking above recommended limits is seen as one risk factor that contributes towards dementia, rather than being a direct cause. Other lifestyle risk factors that raise a person's chances of developing dementia include smoking, lack of exercise and unhealthy diet.
As explained below, regularly drinking at much higher levels than recommended can directly cause problems similar to dementia and so is different.
If you are concerned that you or someone you know is drinking too much alcohol and might need help, see the GP for advice. There are other organisations and charities that also provide support and advice for people with alcohol problems and their families (see 'Other useful organisations').
Some people regularly drink much higher levels than the recommended limits of alcohol. For men, this is more than 50 units per week, and for women, more than 35 units per week. Drinking over this amount not only poses a particularly high risk to someone's health but it also increases the risk of the person becoming addicted. (Alcohol addiction is where someone has become dependent on alcohol. They have an excessive desire to drink and their drinking is causing problems in their daily life.) Alcohol intake at such high levels over several years directly damages the brain, causing alcohol-related brain damage (ARBD) in some people.
Alcohol-related brain damage leads to slightly different symptoms in different people and causes a range of conditions. The most common form of ARBD is alcoholic dementia which may also be called alcohol-related dementia. ARBD also includes Korsakoff's syndrome, which is also called Korsakoff's psychosis.
ARBD is defined as long-term decline in memory or thinking caused by excessive alcohol use and a lack of vitamin B1 (thiamine). Thiamine is needed to provide energy to the body. It is especially important for brain and nerve cells because they use so much energy.
Alcohol misuse causes ARBD in a range of ways. Regular heavy drinking over time damages nerve cells because alcohol is a toxin. It also causes chemical changes in the brain and the shrinkage of brain tissue.
The second way that alcohol misuse leads to ARBD is because it causes thiamine deficiency. This is partly because heavy drinkers tend to not look after themselves and have poor diet. Alcohol also irritates the stomach lining, leading to vomiting and poor absorption of nutrients. Thiamine deficiency also happens because alcohol interferes with the way the body stores and handles the vitamin.
Alcohol can also cause ARBD through repeated head injuries. People who misuse alcohol are more prone to falls and getting into fights.
Finally, heavy drinking damages blood vessels and is linked to high blood pressure, raised cholesterol levels and an increased risk of heart attacks and strokes. All of these conditions can damage the brain.
It is important to note that not all of these factors are equally important in all forms of ARBD or in everyone with the condition.
Reliable figures of the number of people with ARBD are not available and the condition is likely to be under-diagnosed. This is partly because having problems with alcohol still carries a stigma within society, so people may not seek help. Awareness of ARBD even among professionals also varies widely. Alcohol-related brain damage may therefore go undiagnosed or unrecorded in a patient's notes.
Evidence from post mortem studies in the UK shows that ARBD affects about 1 in 200 of the general adult population. Among those with alcoholic addiction, this figure rises to as high as one in three. It is not clear why some people develop ARBD while others do not.
People with ARBD tend to be middle-aged, typically in their 40s or 50s, although they can be younger or older. This is younger than the age at which people most often develop common dementias such as Alzheimer's disease. Alcohol-related brain damage is thought to cause more than 10 per cent of dementia in younger people - defined as those aged under 65.
Alcohol-related brain damage is more common among people in poorer communities. It also affects men much more often than women. However, where women are affected, they tend to develop ARBD at a younger age than men and after fewer years of alcohol misuse. Women are more vulnerable to the effects of alcohol.
Korsakoff's syndrome is a form of ARBD in which the main cause is a clear lack of thiamine. Korsakoff's syndrome is the most well-known form of ARBD and many people think that it is the most common or even only form. However, Korsakoff's syndrome is much less common than other forms of ARBD such as alcoholic dementia.
Korsakoff's syndrome often develops as part of a condition known as Wernicke-Korsakoff syndrome. This consists of two separate but related stages: Wernicke's encephalopathy followed by Korsakoff's syndrome. Wernicke-Korsakoff syndrome is diagnosed in about one in eight people with alcoholism. However, not everyone has a clear case of Wernicke's encephalopathy before Korsakoff's syndrome develops.
An encephalopathy is a disorder that affects the function of the brain. Wernicke's encephalopathy usually develops suddenly, often after abrupt and untreated withdrawal from alcohol. It has a range of different symptoms, but they may not be obvious and it can be difficult to make a diagnosis.
Symptoms of Wernicke's encephalopathy can include:
If Wernicke's encephalopathy is suspected, immediate medical treatment is essential. The person will need high doses of thiamine (and other B vitamins) injected slowly into a vein. If treatment is done in time, most symptoms will be reversed in a few days. However, permanent brain damage may result if Wernicke's encephalopathy is left untreated or is not treated properly or in time. In some severe cases the person may die.
Where Wernicke's encephalopathy is untreated, or is not treated soon enough, Korsakoff's syndrome usually develops, though often gradually. Damage occurs in several regions of the brain - particularly in important small areas deep within the brain, resulting in severe loss of short-term day-to-day memory. Many other abilities may remain intact, such as working memory (information held in our head for a short time before using it, eg working out how much something costs).
The main symptom of Korsakoff's syndrome is loss of day-to-day memory - particularly of events that occur after the onset of the condition. This means that the person may repeat the same question many times. It may also mean they do not recognise someone they have met many times since the start of their condition. In some instances, memories of the more distant past can also be affected. Other symptoms of Korsakoff's syndrome may include:
Recent studies show that a person with Korsakoff's syndrome may also have problems with concentration, planning, making decisions or solving problems. These symptoms are all linked to shrinkage of the front of the brain.
Most people with ARBD do not have the typical symptoms of Korsakoff's syndrome. Instead, they are much more likely to develop alcoholic dementia. This is similar to Korsakoff's syndrome in some ways but different in others. One difference is that alcoholic dementia tends to develop gradually, rather than coming after Wernicke's encephalopathy.
The term 'alcoholic dementia' is widely used because people have problems with memory or reasoning which affect daily life, as in dementia. But calling this form of ARBD 'alcoholic dementia' is not helpful. This is because, if a person with the condition - or any other form of ARBD - remains alcohol-free and gets the right treatment, they have a good chance of improvement over time. (This is unfortunately not the case with progressive dementias such as Alzheimer's disease and vascular dementia.)
In alcoholic dementia the main cause of ARBD is loss of brain tissue, caused by the toxic effects of alcohol misuse over several years. Thiamine deficiency seems to be a less important factor than it is in Korsakoff's syndrome. More areas of the brain are damaged in alcoholic dementia than in many people with Korsakoff's syndrome. A brain scan of someone with alcoholic dementia often shows general brain shrinkage but particular damage to the front of the brain. This area deals with solving problems, setting goals and making decisions, as well as with starting, carrying out and finishing tasks. The front of the brain also controls our motivation, empathy and social behaviour.
As well as shrinkage at the front, the brain of a person with alcoholic dementia also often has shrinkage of the cerebellum. This is the part of the brain at the back of the head that controls balance and posture.
As with Korsakoff's syndrome, the symptoms of alcoholic dementia largely reflect the areas in the person's brain that are damaged. Overall, the symptoms of alcoholic dementia are more varied than those of Korsakoff's. A person with alcoholic dementia often has:
Unlike Korsakoff's syndrome, however, not everyone with alcoholic dementia has loss of day-to-day memory.
Alcohol-related brain damage cannot be reliably diagnosed unless the person has stopped drinking alcohol for several weeks, to enable the symptoms of alcohol intoxication and withdrawal to resolve.
A person's assessment for suspected ARBD follows broadly the same steps as for dementia. The doctor will carry out a full physical examination and take a detailed history from the person and someone who knows them well if possible. This history will include how their symptoms started and how they are currently affecting the person's life. It will also cover the person's history of alcohol use (how much, how often, and for how long). Tests of the person's mental abilities (eg memory, thinking) will also be carried out, as will tests for depression.
A brain scan may also be required. This may rule out other possible causes of symptoms (eg stroke, bleed, tumour). Alternatively, it may show changes such as shrinkage of the cerebellum at the back of the brain, which supports a diagnosis of ARBD rather than dementia.
ARBD should be diagnosed if the person has impaired memory, thinking or reasoning which is bad enough to affect daily life, together with a recent history of several years of alcohol misuse. The person will also be monitored to see whether their condition stabilises or worsens once they are alcohol-free. If their condition continues to worsen, they may be diagnosed with a form of dementia, such as Alzheimer's disease. If they stabilise or improve with abstinence, ARBD is a more likely diagnosis.
Someone will not usually be given a diagnosis of just ARBD but rather a specific form of it. According to the symptoms, the doctor may diagnose Wernicke-Korsakoff syndrome, Korsakoff's alcoholic psychosis, alcoholic dementia, alcohol amnestic syndrome, chronic alcoholic brain syndrome or another condition.
Unlike Alzheimer's disease or vascular dementia, ARBD is not certain to worsen over time. There is a good chance of stabilisation or improvement if the person is given high doses of thiamine, remains free from alcohol and adopts a healthy diet with vitamin supplements. Brain scans show that, with abstinence, some of the damage caused by excessive drinking can be reversed. However, if the person continues to drink and eats poorly, ARBD is likely to continue to progress.
Treatment and support of a person with ARBD is given in two phases: the initial stabilisation phase and longer term rehabilitative care.
During the initial phase of treatment, which usually lasts up to several weeks, the aim is to withdraw alcohol and stabilise the person's medical condition. Most patients with ARBD will need to stay in hospital for this phase.
Withdrawal of alcohol usually causes the person to have delirium (disorientation which varies over time) as well as intense sweating. They will also often have behavioural problems such as agitation and hallucinations. Treatment will include sedation, replacement of lost fluids and salts, and high doses of thiamine by injection.
Unfortunately, many people with ARBD have a lengthy wait in hospital before gaining access to specialist care. Depending on how serious the ARBD, a person could be discharged to residential care, sheltered accommodation or their usual home with support in the community.
After initial stabilisation, a person with ARBD will need ongoing support from two different kinds of services. Professionals in these services should work closely together to ensure the best care for the person.
To stay alcohol-free the person will need support from alcohol treatment services (see 'Other useful organisations'), which also help people with alcohol problems who do not have ARBD. Special drugs will sometimes be prescribed which either reduce the craving for alcohol or make the person feel unwell (or vomit) if they do drink. They will also need to take thiamine tablets and eat well generally.
As well as medication, the person will need non-drug support to stay alcohol-free. This often includes counselling or a 'talking therapy' such as cognitive behavioural therapy focused on their drinking. Support here will also look at a person's social networks and encourage them to attend self-help groups. See 'Other useful organisations' for examples.
Some of the common symptoms of ARBD make it harder for a person with the condition to engage with an alcohol treatment programme. This can include denial, lack of insight and impulsivity. Staying alcohol-free is also more challenging if the person has a complex social setting (eg homelessness, isolated from family due to alcohol misuse). Other medical problems such as drug misuse, poor physical health or depression can also add to the challenge. Addressing these broader aspects is important in helping the person stay alcohol-free.
As well as staying alcohol-free, a person with ARBD will also need rehabilitation to give them the best chance of returning to independent daily living. Rehabilitation is a specialised kind of support that is matched to the person's needs and works towards goals which the person agrees with the professional. It could include practising repetitive strategies to help improve memory, and learning to use memory aids or other supportive technology.
Rehabilitation may come from a dementia service, community mental health team or rehabilitation service for people with acquired brain injury (for example following an accident or stroke). What is available and offered locally - if anything - varies widely across the country.
Any improvement in the person's abilities is usually greatest in the first three months of abstinence but can continue for two to three years. It has been estimated that about a quarter of those affected by ARBD make a very good recovery. About half make a partial recovery and need support to manage their lives, but may still be able to live in their own homes or in sheltered housing. A further quarter make no recovery and generally require long-term residential care.
Other support for someone with ARBD will depend on their individual needs and may be similar to that available for a person with dementia. However, a person with ARBD is usually younger and physically more active than most people with dementia. They may therefore be better suited to services designed for people with young-onset dementia (where these are available) rather than to general dementia day care or residential care. These are generally intended mainly for older people.
It is vital that a professional with experience of supporting people with ARBD is involved in the person's care, regardless of where they live.
Supporting a person with ARBD can be challenging, because of the need for different kinds of support, together with widespread variation in what is available and no clear care 'pathway'. It can mean that the person and any family or friends supporting them experience great frustration in getting the right help. If appropriate support is not available, the person risks falling back into alcohol misuse and going through another cycle of hospitalisation and withdrawal. It is important for the person and anyone supporting them to remain positive and optimistic about the future
( taken from leaflet from Alzheimers society on Alcohol Related Brain